|
gptkbp:instanceOf
|
gptkb:protein
G protein alpha subunit
|
|
gptkbp:activatedBy
|
gptkb:G_protein-coupled_receptors_(GPCRs)
|
|
gptkbp:alternativeName
|
Gαs
stimulatory G protein alpha subunit
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:category
|
gptkb:cell_membrane
signal transduction protein
|
|
gptkbp:component
|
heterotrimeric G protein complex
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman
|
|
gptkbp:EC_number
|
3.6.5.1
|
|
gptkbp:encodedBy
|
gptkb:GNAS_gene
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:fullName
|
gptkb:Guanine_nucleotide-binding_protein_G(s)_subunit_alpha
|
|
gptkbp:function
|
activates adenylyl cyclase
stimulates the production of cAMP
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Gs protein
|
|
gptkbp:inactivationMechanism
|
hydrolysis of GTP to GDP
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:interactsWith
|
gptkb:beta-adrenergic_receptor
adenylyl cyclase
regulator of G protein signaling (RGS) proteins
|
|
gptkbp:involvedIn
|
signal transduction
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
chromosome 20q13.32 (human)
|
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gptkbp:molecularWeight
|
~45 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:McCune-Albright_syndrome
pseudohypoparathyroidism
pituitary tumors
|
|
gptkbp:NobelPrizeYear
|
gptkb:1994_Nobel_Prize_in_Physiology_or_Medicine
|
|
gptkbp:OMIM
|
139320
|
|
gptkbp:postTranslationalModification
|
palmitoylation
myristoylation
|
|
gptkbp:regulates
|
adenylyl cyclase activity
cAMP levels
|
|
gptkbp:relatedTo
|
gptkb:G12/13_protein
gptkb:Gi_protein
gptkb:Gq_protein
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
contains helical domain
contains GTPase domain
|
|
gptkbp:subunit
|
gptkb:G_protein-coupled_receptor
alpha subunit
|
|
gptkbp:UniProtID
|
P63092
|
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gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor
|
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gptkbp:bfsLayer
|
5
|