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gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:activatedBy
|
gptkb:G_protein-coupled_receptor
ligand-bound GPCR
|
|
gptkbp:alphaSubunit
|
Gαi
|
|
gptkbp:betaSubunit
|
Gβ
|
|
gptkbp:composedOf
|
alpha subunit
beta subunit
gamma subunit
|
|
gptkbp:decommissioned
|
GDP binding
GTP hydrolysis
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
GNAI1
GNAI2
GNAI3
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:gammaSubunit
|
Gγ
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Gi protein
|
|
gptkbp:inhibitedBy
|
gptkb:adenylate_cyclase
|
|
gptkbp:involvedIn
|
cellular response to hormones
neurotransmitter signaling
inhibition of adenylyl cyclase
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:modulatedBy
|
gptkb:phospholipase_C
gptkb:MAP_kinase_pathway
ion channels
|
|
gptkbp:namedFor
|
gptkb:Alfred_G._Gilman
inhibitory G protein
|
|
gptkbp:regulates
|
cAMP levels
|
|
gptkbp:relatedTo
|
gptkb:Gq_protein
gptkb:Gs_protein
Go protein
|
|
gptkbp:significance
|
target for drugs
implicated in pertussis toxin action
involved in heart rate regulation
involved in olfaction
involved in opioid receptor signaling
involved in vision
|
|
gptkbp:structure
|
heterotrimer
|
|
gptkbp:subclassOf
|
heterotrimeric G protein
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsLayer
|
5
|