|
gptkbp:instanceOf
|
gptkb:protein
guanine nucleotide exchange factor
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alias
|
gptkb:RHOA
gptkb:Ras_homolog_family_member_A
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
gptkb:GDP_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Alan_Hall
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:encodedBy
|
gptkb:RHOA_gene
|
|
gptkbp:function
|
cell cycle progression
cell migration
cell polarity
cell adhesion
regulation of actin cytoskeleton
smooth muscle contraction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RhoA
|
|
gptkbp:involvedIn
|
signal transduction
wound healing
cancer progression
neuronal development
focal adhesion formation
stress fiber formation
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
3p21.31
|
|
gptkbp:memberOf
|
gptkb:Rho_family
gptkb:small_GTPase_superfamily
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
neurological disorders
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1A2B
|
|
gptkbp:postTranslationalModification
|
prenylation
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:ROCK_(Rho-associated_kinase)
gene expression
cell shape
cell motility
mDia (formin protein)
myosin light chain phosphorylation
|
|
gptkbp:UniProtID
|
P61586
|
|
gptkbp:bfsParent
|
gptkb:RAS_superfamily
|
|
gptkbp:bfsLayer
|
5
|