|
gptkbp:instanceOf
|
gptkb:protein
guanine nucleotide exchange factor
|
|
gptkbp:encodedBy
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gptkb:RAB5A_gene
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:function
|
early endosome fusion
regulation of endocytosis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rab5
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:interactsWith
|
gptkb:EEA1
gptkb:Rabaptin-5
gptkb:Rabex-5
|
|
gptkbp:locale
|
early endosome membrane
|
|
gptkbp:memberOf
|
gptkb:Rab_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:orthologIn
|
gptkb:Ypt51_(yeast)
|
|
gptkbp:postTranslationalModification
|
prenylation
|
|
gptkbp:recruitedFrom
|
gptkb:APPL1
gptkb:EEA1
gptkb:PI3-kinase_Vps34
gptkb:Rab4
gptkb:Rab7
gptkb:Rabaptin-5
gptkb:Rabenosyn-5
gptkb:Rabex-5
|
|
gptkbp:regulates
|
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
gptkb:GDIs_(GDP_dissociation_inhibitors)
signal transduction
autophagy
membrane trafficking
receptor-mediated endocytosis
EGFR trafficking
PI3P production
endocytic vesicle trafficking
endosomal sorting
endosome acidification
endosome maturation
endosome motility
phagosome maturation
transferrin receptor recycling
vesicle docking
vesicle fusion
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
GTPase domain
C-terminal hypervariable region
switch I and II regions
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
endosomal membrane
|
|
gptkbp:bfsParent
|
gptkb:RAS_superfamily
|
|
gptkbp:bfsLayer
|
5
|