Glycogen synthase kinase-3 beta

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:GSK3B gptkb:GSK-3_beta glycogen synthase kinase 3 beta
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:diabetes_mellitus bipolar disorder
gptkbp:discoveredBy	1990
gptkbp:enzymeCommissionNumber	2.7.11.26
gptkbp:function	regulation of apoptosis regulation of cell proliferation regulation of Wnt signaling pathway serine/threonine protein kinase regulation of glycogen metabolism regulation of insulin signaling pathway
gptkbp:gene	gptkb:GSK3B
https://www.w3.org/2000/01/rdf-schema#label	Glycogen synthase kinase-3 beta
gptkbp:inhibitedBy	gptkb:Akt gptkb:insulin lithium
gptkbp:locatedOnChromosome	3q13.33
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	about 46 kDa
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Gsk3b
gptkbp:phosphorylates	gptkb:glycogen_synthase gptkb:tau_protein gptkb:beta-catenin
gptkbp:postTranslationalModification	phosphorylation ubiquitination
gptkbp:proteinFamily	GSK-3 family
gptkbp:regulates	gptkb:synaptic_plasticity gptkb:Wnt_signaling apoptosis cell differentiation embryonic development gene expression inflammation cell cycle neuronal development glycogen metabolism circadian rhythm
gptkbp:structure	contains serine/threonine kinase domain
gptkbp:UniProtID	gptkb:P49841
gptkbp:bfsParent	gptkb:CHEMBL1201585 gptkb:CHEMBL1201582 gptkb:CHEMBL398973 gptkb:GSK-3_beta gptkb:CHEMBL521686 gptkb:CHEMBL1201563
gptkbp:bfsLayer	7