|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
oxidative stress
|
|
gptkbp:alias
|
gptkb:FKHRL1
gptkb:FOXO3A
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
human longevity
|
|
gptkbp:discoveredBy
|
Andrzej K. Bednarek
|
|
gptkbp:encodes
|
Forkhead box protein O3
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000118689
2309
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Forkhead_box_O3
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
HGNC:3819
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Foxo3
|
|
gptkbp:inhibitedBy
|
insulin signaling
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:FOXO1
gptkb:FOXO4
gptkb:SIRT1
gptkb:CBP/p300
gptkb:FOXM1
gptkb:p53
gptkb:SMAD_proteins
|
|
gptkbp:locatedOnChromosome
|
6
|
|
gptkbp:location
|
gptkb:6q21
|
|
gptkbp:memberOf
|
gptkb:FOXO_subfamily
gptkb:forkhead_family
|
|
gptkbp:mutationAssociatedWith
|
affects lifespan
implicated in tumorigenesis
|
|
gptkbp:OMIM
|
602681
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Drosophila_dFOXO
|
|
gptkbp:PDB
|
2UZK
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
|
|
gptkbp:proteinFamily
|
forkhead box proteins
|
|
gptkbp:regulates
|
apoptosis
longevity
DNA repair
metabolism
immune response
cell cycle
autophagy
oxidative stress response
|
|
gptkbp:symbol
|
gptkb:FOXO3
|
|
gptkbp:transcriptionalActivity
|
regulated by phosphorylation
regulated by acetylation
regulated by ubiquitination
|
|
gptkbp:UniProtID
|
O43524
|
|
gptkbp:bfsParent
|
gptkb:FOXO3
|
|
gptkbp:bfsLayer
|
7
|