Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alsoKnownAs |
gptkb:FOXO3
gptkb:FOXO3a |
| gptkbp:associatedWith |
gptkb:cancer
neurodegenerative diseases human longevity |
| gptkbp:discoveredIn |
1999
|
| gptkbp:encodedBy |
FOXO3 gene
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000118689
2309 |
| gptkbp:expressedIn |
many human tissues
|
| gptkbp:function |
transcription factor
|
| gptkbp:HGNC_ID |
gptkb:HGNC:3821
|
| https://www.w3.org/2000/01/rdf-schema#label |
Forkhead box O3
|
| gptkbp:inhibitedBy |
insulin signaling
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_6
|
| gptkbp:memberOf |
Forkhead box O family
|
| gptkbp:orthologInMouse |
gptkb:Foxo3
|
| gptkbp:phosphorylates |
gptkb:AKT1
gptkb:SGK |
| gptkbp:regulates |
apoptosis
longevity DNA repair lipid metabolism metabolism cellular senescence mitochondrial function angiogenesis muscle atrophy inflammation immune response cell cycle stem cell maintenance protein degradation DNA damage response autophagy tumor suppression oxidative stress response insulin sensitivity glucose homeostasis erythropoiesis cellular differentiation cellular proliferation cellular stress resistance |
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:UniProtID |
O43524
|
| gptkbp:bfsParent |
gptkb:FOXO3
|
| gptkbp:bfsLayer |
7
|