Fibroblast Growth Factor Receptor 3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alias	gptkb:JTK4 gptkb:CD333
gptkbp:alternativeSplicing	produces multiple isoforms
gptkbp:approved_drug_target	gptkb:Erdafitinib gptkb:Pemigatinib
gptkbp:associatedWith	gptkb:hypochondroplasia gptkb:thanatophoric_dysplasia gptkb:bladder_cancer achondroplasia
gptkbp:discoveredBy	1990
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000068078
gptkbp:expressedIn	gptkb:cancer gptkb:collagen gptkb:kidney brain
gptkbp:function	cell differentiation cell growth regulation skeletal development
gptkbp:gene	gptkb:FGFR3
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	gptkb:HGNC:3689
gptkbp:interactsWith	gptkb:PLCγ gptkb:FGF1 gptkb:FGF2 gptkb:FGF9 gptkb:GRB2
gptkbp:length	806 amino acids ~16 kb
gptkbp:ligand	fibroblast growth factor
gptkbp:locatedOnChromosome	gptkb:4p16.3
gptkbp:location	gptkb:plasma_membrane
gptkbp:molecularWeight	~95 kDa
gptkbp:mutationAssociatedWith	gptkb:skeletal_dysplasia oncogenesis
gptkbp:OMIM	134934
gptkbp:orthologInMouse	Fgfr3
gptkbp:pathway	gptkb:MAPK_pathway gptkb:PI3K-AKT_pathway gptkb:STAT_pathway
gptkbp:PDB	gptkb:4K33
gptkbp:phosphorylates	tyrosine residues
gptkbp:proteinFamily	gptkb:FGFR_family
gptkbp:UniProtID	gptkb:P22607
gptkbp:bfsParent	gptkb:CD333
gptkbp:bfsLayer	8
http://www.w3.org/2000/01/rdf-schema#label	Fibroblast Growth Factor Receptor 3