Fibroblast Growth Factor Receptor 3

URI: https://gptkb.org/entity/Fibroblast_Growth_Factor_Receptor_3
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alias gptkb:JTK4
gptkb:CD333
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:approved_drug_target gptkb:Erdafitinib
gptkb:Pemigatinib
gptkbp:associatedWith gptkb:hypochondroplasia
gptkb:thanatophoric_dysplasia
bladder cancer
achondroplasia
gptkbp:discoveredBy 1990
gptkbp:Entrez_Gene_ID gptkb:ENSG00000068078
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
brain
collagen
gptkbp:function cell differentiation
cell growth regulation
skeletal development
gptkbp:gene gptkb:FGFR3
gptkbp:geneType protein-coding
gptkbp:HGNC_ID gptkb:HGNC:3689
https://www.w3.org/2000/01/rdf-schema#label Fibroblast Growth Factor Receptor 3
gptkbp:interactsWith gptkb:PLCĪ³
gptkb:FGF1
gptkb:FGF2
gptkb:FGF9
gptkb:GRB2
gptkbp:length 806 amino acids
~16 kb
gptkbp:ligand fibroblast growth factor
gptkbp:locatedOnChromosome gptkb:4p16.3
gptkbp:location gptkb:plasma_membrane
gptkbp:molecularWeight ~95 kDa
gptkbp:mutationAssociatedWith skeletal dysplasia
oncogenesis
gptkbp:OMIM 134934
gptkbp:orthologInMouse Fgfr3
gptkbp:pathway gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
gptkb:STAT_pathway
gptkbp:PDB gptkb:4K33
gptkbp:phosphorylates tyrosine residues
gptkbp:proteinFamily gptkb:FGFR_family
gptkbp:UniProtID gptkb:P22607
gptkbp:bfsParent gptkb:CD333
gptkbp:bfsLayer 7