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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
|
|
gptkbp:alias
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gptkb:CEK2
gptkb:JTK4
gptkb:ACH
gptkb:CD333
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:discoveredBy
|
researchers in the 1990s
|
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gptkbp:domain
|
transmembrane domain
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:encodes
|
gptkb:FGFR3_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000068078
2261
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skin
gptkb:kidney
brain
collagen
|
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_3
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
|
gptkbp:HGNC_ID
|
gptkb:FGFR3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGFR3
|
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gptkbp:involvedIn
|
cell differentiation
cell growth
skeletal development
|
|
gptkbp:ligand
|
gptkb:FGF1
gptkb:FGF18
gptkb:FGF2
gptkb:FGF9
|
|
gptkbp:locatedOnChromosome
|
gptkb:4p16.3
|
|
gptkbp:memberOf
|
gptkb:FGFR_family
receptor tyrosine kinase family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Muenke_syndrome
gptkb:hypochondroplasia
gptkb:thanatophoric_dysplasia
bladder cancer
achondroplasia
|
|
gptkbp:OMIM
|
134934
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:FGF_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1RY7
gptkb:4K33
|
|
gptkbp:phosphorylates
|
gptkb:Y724
gptkb:Y760
|
|
gptkbp:target
|
tyrosine kinase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P22607
|
|
gptkbp:bfsParent
|
gptkb:Lenvima
|
|
gptkbp:bfsLayer
|
5
|