Fibroblast Growth Factor Receptor

URI: https://gptkb.org/entity/Fibroblast_Growth_Factor_Receptor
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:FGFR
gptkbp:activatedBy FGF ligand binding
gptkbp:associatedWith gptkb:cancer
gptkb:bladder_cancer
gptkb:endometrial_cancer
achondroplasia
craniosynostosis syndromes
gptkbp:binds fibroblast growth factor
gptkbp:dimerizesUpon ligand binding
gptkbp:discoveredBy David Givol
gptkbp:discoveredIn 1980s
gptkbp:downstreamOf gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
gptkb:PLCĪ³_pathway
gptkb:STAT_pathway
gptkbp:EC_number 2.7.10.1
gptkbp:expressedIn many tissues
gptkbp:function gptkb:receptor_tyrosine_kinase
gptkbp:gene gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR4
gptkb:FGFR2
gptkbp:involvedIn cell differentiation
cell proliferation
wound healing
angiogenesis
gptkbp:location gptkb:cell_membrane
gptkbp:mutationAssociatedWith gptkb:cancer
skeletal disorders
gptkbp:orthologIn gptkb:meat
gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
gptkbp:phosphorylates tyrosine residues
gptkbp:structure transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:subspecies gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR4
gptkb:FGFR2
gptkbp:target targeted cancer therapies
gptkbp:UniProtID P11362 (FGFR1)
P21802 (FGFR2)
P22455 (FGFR4)
P22607 (FGFR3)
gptkbp:bfsParent gptkb:FGFR
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Fibroblast Growth Factor Receptor