Fibroblast Growth Factor Receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:FGFR
gptkbp:activatedBy	FGF ligand binding
gptkbp:associatedWith	gptkb:cancer gptkb:bladder_cancer gptkb:endometrial_cancer achondroplasia craniosynostosis syndromes
gptkbp:binds	fibroblast growth factor
gptkbp:dimerizesUpon	ligand binding
gptkbp:discoveredBy	David Givol
gptkbp:discoveredIn	1980s
gptkbp:downstreamOf	gptkb:MAPK_pathway gptkb:PI3K-AKT_pathway gptkb:PLCγ_pathway gptkb:STAT_pathway
gptkbp:EC_number	2.7.10.1
gptkbp:expressedIn	many tissues
gptkbp:function	gptkb:receptor_tyrosine_kinase
gptkbp:gene	gptkb:FGFR3 gptkb:FGFR1 gptkb:FGFR4 gptkb:FGFR2
gptkbp:involvedIn	cell differentiation cell proliferation wound healing angiogenesis
gptkbp:location	gptkb:cell_membrane
gptkbp:mutationAssociatedWith	gptkb:cancer skeletal disorders
gptkbp:orthologIn	gptkb:meat gptkb:mouse gptkb:zebrafish gptkb:Drosophila_melanogaster
gptkbp:phosphorylates	tyrosine residues
gptkbp:structure	transmembrane domain extracellular ligand-binding domain intracellular tyrosine kinase domain
gptkbp:subspecies	gptkb:FGFR3 gptkb:FGFR1 gptkb:FGFR4 gptkb:FGFR2
gptkbp:target	targeted cancer therapies
gptkbp:UniProtID	P11362 (FGFR1) P21802 (FGFR2) P22455 (FGFR4) P22607 (FGFR3)
gptkbp:bfsParent	gptkb:FGFR
gptkbp:bfsLayer	7
http://www.w3.org/2000/01/rdf-schema#label	Fibroblast Growth Factor Receptor