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Fibroblast Growth Factor Receptor
URI:
https://gptkb.org/entity/Fibroblast_Growth_Factor_Receptor
GPTKB entity
Statements (50)
Predicate
Object
gptkbp:instanceOf
gptkb:protein
gptkbp:abbreviation
gptkb:FGFR
gptkbp:activatedBy
FGF ligand binding
gptkbp:associatedWith
gptkb:cancer
gptkb:endometrial_cancer
bladder cancer
achondroplasia
craniosynostosis syndromes
gptkbp:binds
fibroblast growth factor
gptkbp:dimerizesUpon
ligand binding
gptkbp:discoveredBy
David Givol
gptkbp:discoveredIn
1980s
gptkbp:downstreamOf
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
gptkb:PLCγ_pathway
gptkb:STAT_pathway
gptkbp:EC_number
2.7.10.1
gptkbp:expressedIn
many tissues
gptkbp:function
gptkb:receptor_tyrosine_kinase
gptkbp:gene
gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR4
gptkb:FGFR2
https://www.w3.org/2000/01/rdf-schema#label
Fibroblast Growth Factor Receptor
gptkbp:involvedIn
cell differentiation
cell proliferation
wound healing
angiogenesis
gptkbp:location
gptkb:cell_membrane
gptkbp:mutationAssociatedWith
gptkb:cancer
skeletal disorders
gptkbp:orthologIn
gptkb:meat
gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
gptkbp:phosphorylates
tyrosine residues
gptkbp:structure
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:subspecies
gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR4
gptkb:FGFR2
gptkbp:target
targeted cancer therapies
gptkbp:UniProtID
P11362 (FGFR1)
P21802 (FGFR2)
P22455 (FGFR4)
P22607 (FGFR3)
gptkbp:bfsParent
gptkb:FGFR
gptkbp:bfsLayer
6