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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:FKHR
gptkb:Forkhead_box_protein_O1
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gptkbp:associatedWith
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gptkb:cancer
gptkb:diabetes_mellitus
gptkb:rhabdomyosarcoma
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gptkbp:biologicalProcess
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apoptotic process
regulation of transcription, DNA-templated
gluconeogenesis
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gptkbp:cellularComponent
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:citation
|
PMID:11788823
PMID:14561782
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gptkbp:domain
|
forkhead DNA-binding domain
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gptkbp:Entrez_Gene_ID
|
2308
ENSG00000150907
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gptkbp:function
|
transcription factor
regulates expression of genes involved in apoptosis, cell cycle control, glucose metabolism, and oxidative stress resistance
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gptkbp:gene
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gptkb:FOXO1
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gptkbp:goMolecularFunction
|
DNA binding
transcription factor activity
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https://www.w3.org/2000/01/rdf-schema#label
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FOXO1 HUMAN
|
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gptkbp:interactsWith
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gptkb:14-3-3_proteins
gptkb:AKT1
gptkb:SMAD3
gptkb:CREBBP
gptkb:SIRT1
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gptkbp:length
|
655 amino acids
|
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gptkbp:locatedOnChromosome
|
13q14.11
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gptkbp:molecularWeight
|
70 kDa
|
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gptkbp:mutationAssociatedWith
|
fusion with PAX3 or PAX7 in alveolar rhabdomyosarcoma
|
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:orthologIn
|
FOXO1_MOUSE
FOXO1_RAT
|
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gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
gptkb:FoxO_signaling_pathway
insulin signaling pathway
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gptkbp:PDB
|
3COA
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gptkbp:phosphorylates
|
Ser256
Ser319
Thr24
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gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
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gptkbp:regulates
|
regulated by AKT-mediated phosphorylation
regulated by insulin signaling
|
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gptkbp:subcellularLocation
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:tissue_specificity
|
gptkb:skeletal_muscle
liver
adipose tissue
pancreas
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gptkbp:UniProtID
|
Q12778
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gptkbp:bfsParent
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gptkb:P48431
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gptkbp:bfsLayer
|
7
|