|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:diseaseRole
|
oncogene in some cancers
|
|
gptkbp:domain
|
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:FGFR3_gene
|
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_3
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3689
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGFR3 protein
|
|
gptkbp:interactsWith
|
gptkb:PLCĪ³
gptkb:FGF1
gptkb:FGF2
gptkb:GRB2
|
|
gptkbp:involvedIn
|
cell differentiation
cell growth regulation
skeletal development
|
|
gptkbp:ligand
|
fibroblast growth factor
|
|
gptkbp:locatedOnChromosome
|
gptkb:4p16.3
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
88 kDa (approximate)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hypochondroplasia
gptkb:thanatophoric_dysplasia
bladder cancer
achondroplasia
|
|
gptkbp:OMIM
|
134934
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:FGF_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1RY7
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:FGFR_family
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:UniProtID
|
gptkb:P22607
|
|
gptkbp:bfsParent
|
gptkb:FGFR3
|
|
gptkbp:bfsLayer
|
6
|