|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
F-box/WD repeat-containing protein 7
SEL-10 homolog
hCDC4
|
|
gptkbp:component
|
gptkb:SCF_ubiquitin_ligase_complex
|
|
gptkbp:discoveredBy
|
Koepp DM et al.
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:domain
|
gptkb:WD40_repeat
F-box domain
|
|
gptkbp:encodedBy
|
FBXW7 gene
|
|
gptkbp:Entrez_Gene_ID
|
55294
ENSG00000109670
|
|
gptkbp:function
|
tumor suppressor
E3 ubiquitin-protein ligase substrate recognition component
|
|
gptkbp:hasIsoform
|
FBXW7α
FBXW7β
FBXW7γ
|
|
gptkbp:HGNC_ID
|
HGNC:16712
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FBXW7 (human)
|
|
gptkbp:involvedIn
|
cell cycle regulation
protein degradation
ubiquitin-mediated proteolysis
|
|
gptkbp:length
|
707 amino acids (canonical isoform)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q31.3
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
gptkb:T-cell_acute_lymphoblastic_leukemia
colorectal cancer
cholangiocarcinoma
|
|
gptkbp:OMIM
|
605566
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Fbxw7
|
|
gptkbp:orthologInYeast
|
Cdc4
|
|
gptkbp:proteinFamily
|
F-box protein family
|
|
gptkbp:RefSeq
|
NM_033632
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:c-Myc
gptkb:Jun
gptkb:mTOR
gptkb:Mcl-1
gptkb:cyclin_E
gptkb:Notch1
|
|
gptkbp:UniProtID
|
Q969H0
|
|
gptkbp:bfsParent
|
gptkb:CDC4
|
|
gptkbp:bfsLayer
|
8
|