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gptkbp:instanceOf
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gptkb:gene
|
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gptkbp:alias
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gptkb:VEGF
gptkb:MVCD1
gptkb:VPF
|
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gptkbp:alternativeSplicing
|
produces multiple isoforms
|
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gptkbp:associatedWith
|
gptkb:cancer
age-related macular degeneration
diabetic retinopathy
pre-eclampsia
|
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gptkbp:biologicalProcess
|
wound healing
tissue regeneration
|
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gptkbp:clinicalTrialPhase
|
VEGF serum level measurement
|
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gptkbp:discoveredBy
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gptkb:Napoleone_Ferrara
|
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gptkbp:encodes
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gptkb:VEGF-A
|
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gptkbp:Entrez_Gene_ID
|
7422
ENSG00000112715
|
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gptkbp:expressedIn
|
embryonic development
endothelial cells
|
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gptkbp:fullName
|
gptkb:vascular_endothelial_growth_factor_A
|
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gptkbp:function
|
stimulates vasculogenesis and angiogenesis
|
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gptkbp:GO:0001525
|
angiogenesis
|
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gptkbp:GO:0008083
|
growth factor activity
|
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gptkbp:GO:0008284
|
positive regulation of cell proliferation
|
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gptkbp:HGNC_ID
|
HGNC:12680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VEGFA gene
|
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gptkbp:length
|
165 amino acids (major isoform)
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:mRNALength
|
~4000 nucleotides
|
|
gptkbp:mutationAssociatedWith
|
hereditary vascular diseases
|
|
gptkbp:OMIM
|
192240
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologInChicken
|
gptkb:VEGFA
|
|
gptkbp:orthologInChimpanzee
|
gptkb:VEGFA
|
|
gptkbp:orthologInCow
|
gptkb:VEGFA
|
|
gptkbp:orthologInDog
|
gptkb:VEGFA
|
|
gptkbp:orthologInFruitFly
|
gptkb:Pvf1
|
|
gptkbp:orthologInMouse
|
gptkb:Vegfa
|
|
gptkbp:orthologInYeast
|
no ortholog
|
|
gptkbp:orthologInZebrafish
|
vegfaa
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
signal peptide cleavage
|
|
gptkbp:proteinFamily
|
PDGF/VEGF domain
PDGF/VEGF growth factor family
|
|
gptkbp:regulates
|
gptkb:HIF1A
upregulated by hypoxia
|
|
gptkbp:targetOfDrug
|
gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
|
|
gptkbp:UniProtID
|
P15692
|
|
gptkbp:usedInTherapy
|
anti-VEGF therapy
|
|
gptkbp:bfsParent
|
gptkb:F-BVFA
|
|
gptkbp:bfsLayer
|
5
|