Vascular endothelial growth factor A

URI: https://gptkb.org/entity/Vascular_endothelial_growth_factor_A
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:VEGF-A
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:biologicalProcess embryonic development
wound healing
vasculogenesis
gptkbp:category growth factor
signaling molecule
gptkbp:discoveredBy gptkb:Napoleone_Ferrara
gptkbp:discoveredIn 1989
gptkbp:encodedBy gptkb:VEGFA_gene
gptkbp:Entrez_Gene_ID 7422
ENSG00000112715
gptkbp:foundIn humans
other mammals
gptkbp:function increases vascular permeability
promotes endothelial cell growth
stimulates angiogenesis
gptkbp:GO GO:0001525 (angiogenesis)
GO:0005178 (integrin binding)
GO:0008285 (negative regulation of cell proliferation)
gptkbp:HGNC_ID HGNC:12680
https://www.w3.org/2000/01/rdf-schema#label Vascular endothelial growth factor A
gptkbp:locatedOnChromosome gptkb:6p21.1
gptkbp:molecularWeight ~27 kDa (monomer)
gptkbp:OMIM 192240
gptkbp:orthologIn gptkb:mouse
right
gptkbp:PDB 1VPF
gptkbp:recipient gptkb:VEGFR-1
gptkb:VEGFR-2
gptkbp:RefSeq NM_003376
gptkbp:regulates upregulated by hypoxia
regulated by HIF-1
gptkbp:role gptkb:cancer
age-related macular degeneration
diabetic retinopathy
gptkbp:structure homodimer
gptkbp:targetOfDrug gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
gptkbp:tissue_specificity gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
heart
retina
liver
gptkbp:UniProtID P15692
gptkbp:bfsParent gptkb:F-BVFA
gptkbp:bfsLayer 5