|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ENX-1
gptkb:Enhancer_of_zeste_2_polycomb_repressive_complex_2_subunit
gptkb:KMT6
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Weaver_syndrome
|
|
gptkbp:biologicalProcess
|
chromatin organization
transcriptional repression
|
|
gptkbp:catalyzes
|
Histone H3 lysine 27 trimethylation
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_2
|
|
gptkbp:diseaseVariant
|
A677G
A682G
Y641F
Y646N
|
|
gptkbp:enzymeClassification
|
EC 2.1.1.43
|
|
gptkbp:expressedIn
|
embryonic stem cells
proliferating cells
|
|
gptkbp:fullName
|
gptkb:Enhancer_of_zeste_homolog_2
|
|
gptkbp:function
|
Histone methyltransferase
|
|
gptkbp:gene
|
gptkb:EZH2
|
|
gptkbp:goMolecularFunction
|
histone methyltransferase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EZH2 HUMAN
|
|
gptkbp:inhibitedBy
|
gptkb:Tazemetostat
gptkb:EPZ-6438
gptkb:GSK126
|
|
gptkbp:interactsWith
|
AEBP2_HUMAN
EED_HUMAN
JARID2_HUMAN
RBBP4_HUMAN
RBBP7_HUMAN
SUZ12_HUMAN
|
|
gptkbp:length
|
751 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q36.1
|
|
gptkbp:molecularWeight
|
85 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:6C23
gptkb:5HYN
5IJ7
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
differentiation
gene silencing
cell cycle
chromatin structure
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
gptkb:Q15910
|
|
gptkbp:bfsParent
|
gptkb:Ezh2
|
|
gptkbp:bfsLayer
|
8
|