mitogen-activated protein kinases

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	MAPKs
gptkbp:activatedBy	cytokines mitogens osmotic stress MAPK kinase (MEK)
gptkbp:component	gptkb:MAPK/ERK_pathway gptkb:MAPK/JNK_pathway gptkb:MAPK/p38_pathway
gptkbp:discoveredBy	1990s
gptkbp:enzymeClassification	gptkb:EC_2.7.11.24
gptkbp:foundIn	eukaryotes
gptkbp:function	signal transduction phosphorylation of target proteins
gptkbp:GO_term	GO:0000165
gptkbp:hasMember	gptkb:ERK1 gptkb:ERK2 gptkb:JNK1 gptkb:JNK2 gptkb:p38_MAPK gptkb:ERK5 gptkb:JNK3
https://www.w3.org/2000/01/rdf-schema#label	mitogen-activated protein kinases
gptkbp:inhibitedBy	MAPK inhibitors
gptkbp:involves	cell cycle regulation cell migration inflammation immune response developmental processes stress response
gptkbp:locale	gptkb:nucleus gptkb:cytoplasm
gptkbp:phosphorylates	transcription factors cytoskeletal proteins other kinases apoptotic regulators
gptkbp:regulates	apoptosis cell differentiation cell proliferation cell survival gene expression cellular response to stress
gptkbp:relatedTo	gptkb:cancer neurodegenerative diseases inflammatory diseases
gptkbp:UniProt_category	gptkb:P27361
gptkbp:bfsParent	gptkb:Extracellular_signal-regulated_kinase gptkb:Mitogen-activated_protein_kinase_pathway
gptkbp:bfsLayer	7