Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:KRAS
|
| gptkbp:established |
apoptosis
feedback mechanisms growth factors cytokines ER K1/2 |
| gptkbp:form |
gptkb:A-Raf
gptkb:B-Raf gptkb:C-Raf |
| gptkbp:genetic_diversity |
gptkb:healthcare_organization
|
| gptkbp:has_method |
phosphorylates MEK
|
| gptkbp:has_role |
signal transduction
|
| https://www.w3.org/2000/01/rdf-schema#label |
Raf kinase
|
| gptkbp:is_aimed_at |
MEK inhibitors
B-Raf inhibitors |
| gptkbp:is_associated_with |
gptkb:healthcare_organization
tumor progression therapeutic resistance |
| gptkbp:is_involved_in |
metabolism
cell cycle regulation cell differentiation cell proliferation cellular homeostasis cellular metabolism cellular stress response immune response inflammation wound healing cell survival cellular aging cellular differentiation cellular development neurogenesis angiogenesis tissue repair neuroprotection cell adhesion cell migration metastasis hormonal regulation cellular communication stem cell maintenance cellular signaling endocrine signaling cellular repair neurotransmitter signaling receptor signaling apoptotic signaling |
| gptkbp:is_part_of |
Raf/ MEK/ ERK pathway
|
| gptkbp:is_represented_in |
various tissues
|
| gptkbp:is_studied_in |
drug development
cancer research |
| gptkbp:located_in |
gptkb:physicist
cytoplasm |
| gptkbp:part_of |
MAPK signaling pathway
|
| gptkbp:regulates |
gptkb:Ras_protein
|