|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:Ras_protein
|
|
gptkbp:associatedWith
|
gptkb:cardiofaciocutaneous_syndrome
gptkb:cancer
melanoma
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:RAF_gene_family
|
|
gptkbp:function
|
serine/threonine-specific protein kinase activity
|
|
gptkbp:hasIsoform
|
gptkb:ARAF
gptkb:BRAF
gptkb:CRAF
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Raf kinase
|
|
gptkbp:inhibitedBy
|
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:protein_kinase_superfamily
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:3OMV
|
|
gptkbp:phosphorylates
|
gptkb:MAP2K1
gptkb:MAP2K2
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:substrate
|
gptkb:MEK
|
|
gptkbp:UniProtID
|
gptkb:P10398_(ARAF)
P04049 (BRAF)
P15056 (CRAF)
|
|
gptkbp:bfsParent
|
gptkb:Ras-binding_domain
gptkb:Drosophila_melanogaster_(D-raf)
gptkb:MAPK/ERK_signaling_pathway
gptkb:Ras/MAPK_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|