Dual specificity protein phosphatase 1

URI: https://gptkb.org/entity/Dual_specificity_protein_phosphatase_1
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:actsOn phosphotyrosine
phosphoserine
phosphothreonine
gptkbp:alternativeName gptkb:CL100
gptkb:ERK_phosphatase
gptkb:HVH1
gptkb:MKP-1
gptkbp:Entrez_Gene_ID 1843
gptkbp:enzymeCommissionNumber 3.1.3.16
gptkbp:expressedIn various tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function dephosphorylation of MAP kinases
gptkbp:gene gptkb:DUSP1
gptkbp:HGNC_ID 3071
gptkbp:inducedBy gptkb:glucocorticoids
stress
growth factors
oxidative stress
gptkbp:inhibitedBy MAPK activity
gptkbp:involves gptkb:MAPK_signaling_pathway
cellular response to oxidative stress
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome chromosome 5q35.1
gptkbp:molecularWeight ~39 kDa
gptkbp:OMIM 600714
gptkbp:PDB gptkb:1MKP
gptkbp:RefSeq NM_004417
gptkbp:regulates gptkb:MAPK/ERK_pathway
gptkb:immune_response
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
apoptosis
cell differentiation
cell proliferation
gene expression
cellular senescence
cell cycle
inflammatory response
cytokine production
cellular response to stress
apoptotic signaling pathway
response to DNA damage stimulus
gptkbp:UniProtID gptkb:P28562
gptkbp:bfsParent gptkb:DUSP1
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Dual specificity protein phosphatase 1