Dual specificity protein phosphatase 1

URI: https://gptkb.org/entity/Dual_specificity_protein_phosphatase_1
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:actsOn phosphotyrosine
phosphoserine
phosphothreonine
gptkbp:alternativeName gptkb:CL100
gptkb:ERK_phosphatase
gptkb:HVH1
gptkb:MKP-1
gptkbp:Entrez_Gene_ID 1843
gptkbp:enzymeCommissionNumber 3.1.3.16
gptkbp:expressedIn various tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function dephosphorylation of MAP kinases
gptkbp:gene gptkb:DUSP1
gptkbp:HGNC_ID 3071
https://www.w3.org/2000/01/rdf-schema#label Dual specificity protein phosphatase 1
gptkbp:inducedBy gptkb:glucocorticoids
stress
growth factors
oxidative stress
gptkbp:inhibitedBy MAPK activity
gptkbp:involves gptkb:MAPK_signaling_pathway
cellular response to oxidative stress
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome chromosome 5q35.1
gptkbp:molecularWeight ~39 kDa
gptkbp:OMIM 600714
gptkbp:PDB gptkb:1MKP
gptkbp:RefSeq NM_004417
gptkbp:regulates gptkb:MAPK/ERK_pathway
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
apoptosis
cell differentiation
cell proliferation
gene expression
cellular senescence
immune response
cell cycle
inflammatory response
cytokine production
cellular response to stress
apoptotic signaling pathway
response to DNA damage stimulus
gptkbp:UniProtID gptkb:P28562
gptkbp:bfsParent gptkb:DUSP1
gptkbp:bfsLayer 7