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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:DUSP1
Dual specificity phosphatase 1
|
|
gptkbp:discoveredBy
|
1995
|
|
gptkbp:encodedBy
|
DUSP1 gene
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.1.3.16
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Mitogen-activated protein kinase phosphatase 1
|
|
gptkbp:function
|
dephosphorylates MAP kinases
|
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gptkbp:gene
|
gptkb:DUSP1
|
|
gptkbp:HGNC_ID
|
HGNC:3071
|
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gptkbp:inducedBy
|
gptkb:glucocorticoids
stress
growth factors
oxidative stress
|
|
gptkbp:inhibitedBy
|
gptkb:JNK
gptkb:p38_MAPK
gptkb:ERK
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q35.1
|
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gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~39 kDa
|
|
gptkbp:OMIM
|
600714
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:regulates
|
gptkb:immune_response
gptkb:MAPK_signaling_pathway
inflammatory cytokine production
|
|
gptkbp:role
|
gptkb:cellular_stress_response
apoptosis
cell proliferation
inflammation regulation
|
|
gptkbp:significance
|
implicated in neurodegenerative diseases
potential target in cancer therapy
implicated in metabolic diseases
|
|
gptkbp:structure
|
contains dual specificity phosphatase domain
|
|
gptkbp:UniProtID
|
gptkb:P28562
|
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gptkbp:bfsParent
|
gptkb:DUSP1
|
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gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MKP-1
|