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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:DUSP1
Dual specificity phosphatase 1
|
|
gptkbp:discoveredBy
|
1995
|
|
gptkbp:encodedBy
|
DUSP1 gene
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gptkbp:enzymeClassification
|
gptkb:EC_3.1.3.16
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gptkbp:expressedIn
|
various tissues
|
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gptkbp:fullName
|
Mitogen-activated protein kinase phosphatase 1
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gptkbp:function
|
dephosphorylates MAP kinases
|
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gptkbp:gene
|
gptkb:DUSP1
|
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gptkbp:HGNC_ID
|
HGNC:3071
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MKP-1
|
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gptkbp:inducedBy
|
gptkb:glucocorticoids
stress
growth factors
oxidative stress
|
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gptkbp:inhibitedBy
|
gptkb:JNK
gptkb:p38_MAPK
gptkb:ERK
|
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gptkbp:locatedOnChromosome
|
chromosome 5q35.1
|
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gptkbp:location
|
gptkb:nucleus
|
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gptkbp:molecularWeight
|
~39 kDa
|
|
gptkbp:OMIM
|
600714
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:regulates
|
gptkb:MAPK_signaling_pathway
immune response
inflammatory cytokine production
|
|
gptkbp:role
|
apoptosis
cell proliferation
cellular stress response
inflammation regulation
|
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gptkbp:significance
|
implicated in neurodegenerative diseases
potential target in cancer therapy
implicated in metabolic diseases
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gptkbp:structure
|
contains dual specificity phosphatase domain
|
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gptkbp:UniProtID
|
gptkb:P28562
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gptkbp:bfsParent
|
gptkb:DUSP1
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gptkbp:bfsLayer
|
7
|