|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:BCL1
gptkb:PRAD1
U21B31
|
|
gptkbp:binds
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:degradationPathway
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:degradedBy
|
gptkb:SCF_ubiquitin_ligase_complex
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:CCND1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:CCND1
ENSG00000110092
|
|
gptkbp:exportedFromNucleusBy
|
CRM1
|
|
gptkbp:function
|
regulation of cell cycle
|
|
gptkbp:HGNC_ID
|
1582
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cyclin D1 protein
|
|
gptkbp:involvedIn
|
G1/S cell cycle transition
|
|
gptkbp:involves
|
gptkb:mantle_cell_lymphoma
gptkb:cancer
gptkb:head_and_neck_squamous_cell_carcinoma
colorectal cancer
esophageal cancer
melanoma
prostate cancer
parathyroid adenoma
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q13
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:OMIM
|
168461
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
|
|
gptkbp:PDB
|
gptkb:2W96
|
|
gptkbp:phosphorylates
|
gptkb:GSK3β
Thr286
|
|
gptkbp:RefSeq
|
NP_444284.1
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:Wnt_signaling_pathway
gptkb:retinoblastoma_protein_(pRb)
cell differentiation
cell proliferation
DNA repair
transcription
metabolism
growth factors
estrogen
oncogenic signals
|
|
gptkbp:structure
|
contains cyclin box domain
|
|
gptkbp:UniProtID
|
P24385
|
|
gptkbp:bfsParent
|
gptkb:CCND1_gene
|
|
gptkbp:bfsLayer
|
8
|