|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeSiteResidue
|
Cys-163
His-121
|
|
gptkbp:alternativeName
|
gptkb:Yama
gptkb:Apopain
gptkb:CPP32
gptkb:Caspase-3
|
|
gptkbp:cleavage
|
p12 subunit
p17 subunit
|
|
gptkbp:disulfideBond
|
between Cys-148 and Cys-184
between Cys-184 and Cys-220
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.4.22.56
|
|
gptkbp:function
|
cysteine-aspartic acid protease activity
|
|
gptkbp:gene
|
gptkb:CASP3
|
|
gptkbp:GOProcess
|
execution phase of apoptosis
|
|
gptkbp:hasComponent
|
gptkb:nucleus
cytosol
|
|
gptkbp:hasDiseaseAssociation
|
gptkb:Alzheimer's_disease
gptkb:cancer
Neurodegenerative diseases
|
|
gptkbp:hasEnzymeRegulation
|
activated by cytochrome c/Apaf-1/caspase-9 complex
inhibited by XIAP
|
|
gptkbp:hasGOFunction
|
cysteine-type endopeptidase activity
|
|
gptkbp:hasIsoform
|
gptkb:P49918-1
gptkb:P49918-10
gptkb:P49918-2
gptkb:P49918-3
gptkb:P49918-4
gptkb:P49918-5
gptkb:P49918-6
gptkb:P49918-7
gptkb:P49918-8
gptkb:P49918-9
|
|
gptkbp:hasPfamDomain
|
gptkb:PF00656
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P49918
|
|
gptkbp:InterPro
|
gptkb:IPR002398
|
|
gptkbp:involvedIn
|
apoptosis
proteolysis
|
|
gptkbp:isProteaseFamily
|
C14
|
|
gptkbp:locatedOnChromosome
|
4
4q34
|
|
gptkbp:molecularWeight
|
31677 Da
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Q9QZQ4_(mouse)
Q28021 (rat)
|
|
gptkbp:pathway
|
KEGG:hsa04210 (Apoptosis)
Reactome:R-HSA-109581 (Apoptosis)
|
|
gptkbp:PDB
|
gptkb:1CP3
gptkb:1PAU
gptkb:3DEI
2H5I
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequence
|
277
|
|
gptkbp:signalPeptide
|
no
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:transmembraneDomains
|
no
|
|
gptkbp:UniProtID
|
gptkb:P49918
|
|
gptkbp:bfsParent
|
gptkb:CDKN1C
gptkb:p57
|
|
gptkbp:bfsLayer
|
6
|