Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:CD152
gptkb:Cytotoxic_T-lymphocyte-associated_protein_4 |
| gptkbp:binds |
gptkb:CD80
gptkb:CD86 |
| gptkbp:discoveredIn |
1995
|
| gptkbp:encodedBy |
gptkb:CTLA4_gene
|
| gptkbp:expressedIn |
gptkb:T_cells
|
| gptkbp:foundIn |
humans
mice |
| gptkbp:function |
immunotherapy
downregulation of immune responses |
| https://www.w3.org/2000/01/rdf-schema#label |
CTLA-4 protein
|
| gptkbp:inhibitedBy |
CD28-mediated co-stimulation
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_2q33_(human)
|
| gptkbp:molecularWeight |
~25-30 kDa
|
| gptkbp:OMIM |
123890
|
| gptkbp:regulates |
T cell activation
|
| gptkbp:significance |
associated with autoimmune diseases
target for cancer immunotherapy |
| gptkbp:structure |
gptkb:immunoglobulin_superfamily
|
| gptkbp:therapeuticTargetOf |
gptkb:abatacept
gptkb:belatacept gptkb:ipilimumab |
| gptkbp:UniProtID |
P16410
|
| gptkbp:bfsParent |
gptkb:CTLA4_gene
|
| gptkbp:bfsLayer |
7
|