|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD152
|
|
gptkbp:associatedWith
|
immunotherapy
autoimmune diseases
|
|
gptkbp:cellSurfaceMarker
|
true
|
|
gptkbp:clinicalTrialPhase
|
gptkb:abatacept
gptkb:ipilimumab
|
|
gptkbp:discoveredBy
|
gptkb:Pierre_Golstein
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:domain
|
Ig-like V-type domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000163599
1493
|
|
gptkbp:expressedIn
|
gptkb:T_cells
|
|
gptkbp:fullName
|
gptkb:Cytotoxic_T-lymphocyte-associated_protein_4
|
|
gptkbp:function
|
immunotherapy
negative regulator of T-cell activation
|
|
gptkbp:geneLocationEnd
|
203873965
|
|
gptkbp:geneLocationStart
|
203867771
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasIsoform
|
full-length CTLA4
soluble CTLA4
|
|
gptkbp:hasPolymorphism
|
+49A/G
CT60
|
|
gptkbp:hasPromoter
|
TATA-less
|
|
gptkbp:HGNC_ID
|
2504
|
|
gptkbp:homologInHuman
|
gptkb:CD28
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CTLA4
|
|
gptkbp:inhibitedBy
|
T cell proliferation
IL-2 production
|
|
gptkbp:interactsWith
|
gptkb:CD80
gptkb:CD86
|
|
gptkbp:length
|
223 amino acids
|
|
gptkbp:locatedOnChromosome
|
plus
2q33.2
|
|
gptkbp:memberOf
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:molecularWeight
|
25 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
gptkb:systemic_lupus_erythematosus
Graves' disease
type 1 diabetes
rheumatoid arthritis
|
|
gptkbp:OMIM
|
123890
|
|
gptkbp:orthologInMouse
|
Ctla4
|
|
gptkbp:PDB
|
1AH1
|
|
gptkbp:regulates
|
immune response
upregulated upon T cell activation
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:target
|
gptkb:abatacept
gptkb:belatacept
gptkb:ipilimumab
|
|
gptkbp:transmembraneDomains
|
true
|
|
gptkbp:UniProtID
|
P16410
|
|
gptkbp:bfsParent
|
gptkb:CTLA4_gene
gptkb:Cytotoxic_T-lymphocyte-associated_protein_4
gptkb:chromosome_2q33
|
|
gptkbp:bfsLayer
|
7
|