Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:CTLA-4
gptkb:Cytotoxic_T-lymphocyte-associated_protein_4 |
| gptkbp:binds |
gptkb:CD80
gptkb:CD86 |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:encodedBy |
gptkb:CTLA4_gene
|
| gptkbp:enemyOf |
gptkb:tremelimumab
gptkb:ipilimumab |
| gptkbp:expressedIn |
gptkb:T_cells
|
| gptkbp:foundIn |
humans
mice |
| gptkbp:function |
immunotherapy
downregulates immune responses |
| https://www.w3.org/2000/01/rdf-schema#label |
CD152
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_2q33_(human)
|
| gptkbp:memberOf |
gptkb:immunoglobulin_superfamily
|
| gptkbp:regulates |
T cell activation
|
| gptkbp:significance |
associated with autoimmune diseases
target for cancer immunotherapy |
| gptkbp:structure |
transmembrane protein
|
| gptkbp:bfsParent |
gptkb:CTLA-4
|
| gptkbp:bfsLayer |
6
|