Cytotoxic T-lymphocyte-associated protein 4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein immunotherapy
gptkbp:abbreviation	gptkb:CTLA-4
gptkbp:alternativeName	gptkb:CD152
gptkbp:associatedWith	immunotherapy autoimmune diseases
gptkbp:binds	gptkb:CD80 gptkb:CD86
gptkbp:category	cell surface receptor immune system protein
gptkbp:discoveredBy	gptkb:Pierre_Golstein
gptkbp:discoveredIn	1987
gptkbp:encodedBy	gptkb:CTLA4_gene
gptkbp:enemyOf	gptkb:tremelimumab gptkb:ipilimumab
gptkbp:expressedIn	gptkb:regulatory_T_cells activated T cells
gptkbp:foundIn	humans other mammals
gptkbp:function	regulates immune response inhibits T cell activation
gptkbp:gene	gptkb:CTLA4
gptkbp:HGNC_ID	2504
https://www.w3.org/2000/01/rdf-schema#label	Cytotoxic T-lymphocyte-associated protein 4
gptkbp:inhibitedBy	CD28-mediated co-stimulation
gptkbp:length	223 amino acids
gptkbp:locatedOnChromosome	chromosome 2
gptkbp:location	gptkb:cell_membrane intracellular vesicles
gptkbp:medicalUse	target for immune checkpoint blockade
gptkbp:memberOf	gptkb:immunoglobulin_superfamily
gptkbp:mutationAssociatedWith	gptkb:systemic_lupus_erythematosus Graves' disease type 1 diabetes autoimmune thyroid disease
gptkbp:OMIM	123890
gptkbp:regulates	T cell activation T cell proliferation immune tolerance
gptkbp:structure	single-pass type I membrane protein
gptkbp:target	gptkb:tremelimumab gptkb:ipilimumab
gptkbp:UniProtID	P16410
gptkbp:bfsParent	gptkb:CTLA-4
gptkbp:bfsLayer	6