Cytotoxic T-lymphocyte-associated protein 4

URI: https://gptkb.org/entity/Cytotoxic_T-lymphocyte-associated_protein_4
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:immunotherapy
gptkb:protein
gptkbp:abbreviation gptkb:CTLA-4
gptkbp:alternativeName gptkb:CD152
gptkbp:associatedWith gptkb:immunotherapy
autoimmune diseases
gptkbp:binds gptkb:CD80
gptkb:CD86
gptkbp:category gptkb:cell_surface_receptor
immune system protein
gptkbp:discoveredBy gptkb:Pierre_Golstein
gptkbp:discoveredIn 1987
gptkbp:encodedBy gptkb:CTLA4_gene
gptkbp:enemyOf gptkb:tremelimumab
gptkb:ipilimumab
gptkbp:expressedIn gptkb:regulatory_T_cells
activated T cells
gptkbp:foundIn humans
other mammals
gptkbp:function regulates immune response
inhibits T cell activation
gptkbp:gene gptkb:CTLA4
gptkbp:HGNC_ID 2504
gptkbp:inhibitedBy CD28-mediated co-stimulation
gptkbp:length 223 amino acids
gptkbp:locatedOnChromosome chromosome 2
gptkbp:location gptkb:cell_membrane
intracellular vesicles
gptkbp:medicalUse target for immune checkpoint blockade
gptkbp:memberOf gptkb:immunoglobulin_superfamily
gptkbp:mutationAssociatedWith gptkb:systemic_lupus_erythematosus
Graves' disease
type 1 diabetes
autoimmune thyroid disease
gptkbp:OMIM 123890
gptkbp:regulates T cell activation
T cell proliferation
immune tolerance
gptkbp:structure single-pass type I membrane protein
gptkbp:target gptkb:tremelimumab
gptkb:ipilimumab
gptkbp:UniProtID P16410
gptkbp:bfsParent gptkb:CTLA-4
gptkbp:bfsLayer 6
https://www.w3.org/2000/01/rdf-schema#label Cytotoxic T-lymphocyte-associated protein 4