|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alias
|
prostaglandin-endoperoxide synthase 2
Cox-2
PGHS-2
hCox-2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
fever
pain
inflammation
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:discoveredBy
|
gptkb:Daniel_Simmons
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:EC_number
|
1.14.99.1
|
|
gptkbp:encodedBy
|
gptkb:PTGS2_gene
|
|
gptkbp:Entrez_Gene_ID
|
5743
|
|
gptkbp:fullName
|
Cyclooxygenase-2
|
|
gptkbp:function
|
catalyzes conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:gene
|
gptkb:PTGS2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
COX2
|
|
gptkbp:inducedBy
|
cytokines
growth factors
tumor promoters
|
|
gptkbp:inhibitedBy
|
gptkb:ibuprofen
gptkb:NSAIDs
gptkb:rofecoxib
gptkb:aspirin
gptkb:celecoxib
|
|
gptkbp:locatedOnChromosome
|
1q31.1
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
nuclear envelope
|
|
gptkbp:molecularWeight
|
approximately 72 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Canis_lupus_familiaris
gptkb:Rattus_norvegicus
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
colorectal cancer
rheumatoid arthritis
|
|
gptkbp:pathway
|
prostaglandin biosynthesis
|
|
gptkbp:PDB
|
5F19
1CVU
1PXX
3LN1
6COX
|
|
gptkbp:product
|
prostaglandin H2
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
|
|
gptkbp:UniProtID
|
P35354
|
|
gptkbp:bfsParent
|
gptkb:COX1
gptkb:cytochrome_c_oxidase_complex
|
|
gptkbp:bfsLayer
|
7
|