|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:COX-2
cyclooxygenase-2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:cardiovascular_disease
inflammatory diseases
|
|
gptkbp:biologicalProcess
|
regulation of cell proliferation
inflammatory response
fever response
pain response
peroxidase activity
prostaglandin-endoperoxide synthase activity
|
|
gptkbp:cellularComponent
|
gptkb:endoplasmic_reticulum
nuclear envelope
|
|
gptkbp:discoveredBy
|
gptkb:Daniel_Simmons
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
prostaglandin-endoperoxide synthase 2
|
|
gptkbp:Entrez_Gene_ID
|
5743
ENSG00000073756
|
|
gptkbp:expressedIn
|
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:fullName
|
prostaglandin-endoperoxide synthase 2
|
|
gptkbp:function
|
catalyzes conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:GeneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9605
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTGS2 gene
|
|
gptkbp:inducedBy
|
cytokines
growth factors
tumor promoters
|
|
gptkbp:length
|
604 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q31.1
|
|
gptkbp:molecularWeight
|
69 kDa
|
|
gptkbp:OMIM
|
600262
|
|
gptkbp:orthologIn
|
gptkb:lion
gptkb:mouse
right
|
|
gptkbp:product
|
homodimer
|
|
gptkbp:regulates
|
gptkb:CREB
gptkb:NF-kappaB
gptkb:AP-1
inducible
|
|
gptkbp:targetOfDrug
|
gptkb:NSAIDs
gptkb:rofecoxib
gptkb:celecoxib
|
|
gptkbp:UniProtID
|
P35354
|
|
gptkbp:bfsParent
|
gptkb:PG6
gptkb:Prostaglandin_G/H_synthase_2
|
|
gptkbp:bfsLayer
|
7
|