|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:COX-2
cyclooxygenase-2
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
fever
pain
inflammation
|
|
gptkbp:discoveredBy
|
gptkb:Daniel_Simmons
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
prostaglandin-endoperoxide synthase 2
|
|
gptkbp:Entrez_Gene_ID
|
5743
|
|
gptkbp:enzymeClassification
|
gptkb:EC_1.14.99.1
|
|
gptkbp:expressedIn
|
inflammatory cells
|
|
gptkbp:fullName
|
prostaglandin-endoperoxide synthase 2
|
|
gptkbp:function
|
catalyzes conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
9605
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTGS2
|
|
gptkbp:inducedBy
|
cytokines
growth factors
tumor promoters
|
|
gptkbp:inhibitedBy
|
gptkb:NSAIDs
gptkb:rofecoxib
gptkb:celecoxib
|
|
gptkbp:length
|
604 amino acids
|
|
gptkbp:locatedOnChromosome
|
1q31.1
|
|
gptkbp:molecularWeight
|
69 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:cardiovascular_disease
increased cancer risk
|
|
gptkbp:notConstitutivelyExpressed
|
true
|
|
gptkbp:OMIM
|
600262
|
|
gptkbp:orthologInChimpanzee
|
gptkb:PTGS2
|
|
gptkbp:orthologInCow
|
gptkb:PTGS2
|
|
gptkbp:orthologInDog
|
gptkb:PTGS2
|
|
gptkbp:orthologInMouse
|
Ptgs2
|
|
gptkbp:pathway
|
inflammatory response
prostaglandin biosynthesis
arachidonic acid metabolism
|
|
gptkbp:regulates
|
inducible
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
nuclear envelope
|
|
gptkbp:target
|
gptkb:diclofenac
gptkb:ibuprofen
gptkb:parecoxib
gptkb:valdecoxib
gptkb:naproxen
gptkb:etoricoxib
gptkb:aspirin
indomethacin
meloxicam
|
|
gptkbp:UniProtID
|
P35354
|
|
gptkbp:bfsParent
|
gptkb:DB00169
gptkb:CHEMBL960
|
|
gptkbp:bfsLayer
|
6
|