|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:JHDM3B
gptkb:JMJD2B
|
|
gptkbp:associatedWith
|
gptkb:cancer
prostate cancer
|
|
gptkbp:cofactor
|
gptkb:2-oxoglutarate
Fe(II)
|
|
gptkbp:domain
|
gptkb:Tudor_domain
gptkb:JmjN_domain
PHD-type zinc finger
JmjC domain
|
|
gptkbp:downregulatedIn
|
gptkb:hypoxia
|
|
gptkbp:encodes
|
gptkb:Lysine-specific_demethylase_4B
|
|
gptkbp:Entrez_Gene_ID
|
23030
ENSG00000104951
|
|
gptkbp:enzymeCommissionNumber
|
1.14.11.-
|
|
gptkbp:expressedIn
|
gptkb:nucleus
various tissues
|
|
gptkbp:function
|
histone demethylase
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:29011
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KDM4B
|
|
gptkbp:interactsWith
|
gptkb:p53
gptkb:androgen_receptor
estrogen receptor alpha
|
|
gptkbp:involvedIn
|
epigenetic regulation
transcriptional regulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:OMIM
|
609765
|
|
gptkbp:orthologInMouse
|
gptkb:Kdm4b
|
|
gptkbp:phosphorylates
|
gptkb:ATM_kinase
gptkb:CHK2
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
embryonic development
gene expression
DNA damage response
stem cell pluripotency
hormone response
|
|
gptkbp:removesMethylGroupFrom
|
gptkb:H3K36me3
gptkb:H3K9me3
|
|
gptkbp:target
|
small molecule inhibitors
microRNAs
|
|
gptkbp:UniProtID
|
gptkb:O94953
|
|
gptkbp:upregulatedBy
|
several cancers
|
|
gptkbp:bfsParent
|
gptkb:19p13.3
|
|
gptkbp:bfsLayer
|
6
|