CDK (Cyclin-dependent kinase)

URI: https://gptkb.org/entity/CDK_(Cyclin-dependent_kinase)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:abbreviation gptkb:CDK
gptkbp:activityRegulatedBy gptkb:CDK_inhibitors_(CKIs)
phosphorylation
dephosphorylation
cyclin binding
gptkbp:discoveredBy gptkb:Paul_Nurse
gptkb:Tim_Hunt
gptkb:Leland_H._Hartwell
gptkbp:EC_number 2.7.11.22
gptkbp:form CDK-cyclin complex
gptkbp:foundIn eukaryotes
gptkbp:function regulation of cell cycle
https://www.w3.org/2000/01/rdf-schema#label CDK (Cyclin-dependent kinase)
gptkbp:inhibitedBy CDK inhibitors
gptkbp:involvedIn gptkb:G1/S_transition
meiosis
mitosis
G2/M transition
gptkbp:NobelPrizeYear gptkb:2001_Nobel_Prize_in_Physiology_or_Medicine
gptkbp:phosphorylates target proteins
gptkbp:proteinFamily gptkb:CDK7
gptkb:CDK9
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:CDK1
gptkbp:regulates transcription
cell division
DNA replication
gptkbp:relatedTo gptkb:Rb_protein
gptkb:cancer
gptkb:p21_protein
gptkb:p53_protein
apoptosis
cell proliferation
cellular senescence
transcription regulation
cell cycle checkpoints
tumor suppressor proteins
Wee1 kinase
checkpoint kinases
Cdc25 phosphatase
p27 protein
gptkbp:requires gptkb:cyclin
gptkbp:structure serine/threonine kinase domain
gptkbp:target anticancer drugs
gptkbp:bfsParent gptkb:CMGC
gptkbp:bfsLayer 7