|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:alternativeName
|
gptkb:interferon_gamma
type II interferon
|
|
gptkbp:approvedDrugName
|
interferon gamma-1b
|
|
gptkbp:discoveredBy
|
E. F. Wheelock
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:encodedBy
|
gptkb:IFNG_gene
|
|
gptkbp:function
|
immune response regulation
antiviral activity
activation of macrophages
induction of MHC class II expression
promotion of antigen presentation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IFN-gamma
|
|
gptkbp:inducedBy
|
expression of MHC class I
expression of MHC class II
|
|
gptkbp:inhibitedBy
|
Th2 immune response
|
|
gptkbp:involvedIn
|
infectious diseases
autoimmune diseases
cancer immunology
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12_(human)
|
|
gptkbp:measures
|
gptkb:ELISA
flow cytometry
|
|
gptkbp:medicalUse
|
treatment of chronic granulomatous disease
treatment of osteopetrosis
|
|
gptkbp:producedBy
|
gptkb:NK_cells
gptkb:T_cells
|
|
gptkbp:promotion
|
macrophage activation
|
|
gptkbp:recipient
|
IFN-gamma receptor
|
|
gptkbp:regulates
|
gptkb:Th1_immune_response
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:bfsParent
|
gptkb:ICAM-1
gptkb:natural_killer_cells
gptkb:IFNG_gene
gptkb:Th17_cells
gptkb:cytotoxic_T_cell_(CD8+)
|
|
gptkbp:bfsLayer
|
7
|