Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alias |
gptkb:cytokine_synthesis_inhibitory_factor
gptkb:TGIF CSIF |
| gptkbp:associatedWith |
autoimmune diseases
inflammatory diseases |
| gptkbp:discoveredIn |
1990
|
| gptkbp:downregulatedIn |
MHC class II expression
costimulatory molecules |
| gptkbp:encodedBy |
IL10 gene
|
| gptkbp:Entrez_Gene_ID |
3586
|
| gptkbp:expressedIn |
immune cells
|
| gptkbp:fullName |
Interleukin-10
|
| gptkbp:function |
anti-inflammatory cytokine
|
| gptkbp:gene |
gptkb:IL10
|
| gptkbp:HGNC_ID |
HGNC:5962
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-10
|
| gptkbp:inhibitedBy |
antigen presentation
macrophage activation IFN-gamma production IL-1 production IL-6 production TNF-alpha production synthesis of pro-inflammatory cytokines IL-12 production NF-kB activity Th1 cytokine production |
| gptkbp:locatedOnChromosome |
chromosome 1q32.1
|
| gptkbp:modulatedBy |
gptkb:JAK-STAT_signaling_pathway
|
| gptkbp:molecularWeight |
18 kDa (monomer)
|
| gptkbp:OMIM |
124092
|
| gptkbp:orthologIn |
mouse IL-10
|
| gptkbp:producedBy |
gptkb:B_cells
gptkb:T_cells dendritic cells macrophages monocytes |
| gptkbp:promotion |
B cell proliferation
antibody production |
| gptkbp:recipient |
IL-10 receptor
|
| gptkbp:regulates |
inflammation
immune response tissue homeostasis |
| gptkbp:secretes |
yes
|
| gptkbp:structure |
homodimer
|
| gptkbp:therapeuticPotential |
treatment of psoriasis
treatment of rheumatoid arthritis treatment of inflammatory bowel disease |
| gptkbp:UniProtID |
gptkb:P22301
|
| gptkbp:bfsParent |
gptkb:regulatory_T_cells
gptkb:IL-13 gptkb:Th17_cells gptkb:Th2_cells gptkb:Treg_cells |
| gptkbp:bfsLayer |
7
|