Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alternativeName |
colony-stimulating factor 2
|
| gptkbp:discoveredIn |
1977
|
| gptkbp:Entrez_Gene_ID |
1437
ENSG00000164400 |
| gptkbp:fullName |
Granulocyte-macrophage colony-stimulating factor
|
| gptkbp:function |
activates mature granulocytes and macrophages
stimulates stem cells to produce granulocytes and monocytes promotes differentiation of myeloid progenitors |
| gptkbp:gene |
CSF2
|
| gptkbp:halfLife |
short
|
| gptkbp:HGNC_ID |
2434
|
| gptkbp:homology |
shares homology with IL-3 and IL-5
|
| https://www.w3.org/2000/01/rdf-schema#label |
GM-CSF
|
| gptkbp:locatedOnChromosome |
5q31
|
| gptkbp:medicalUse |
immunotherapy
bone marrow recovery after chemotherapy treatment of neutropenia |
| gptkbp:molecularWeight |
14-35 kDa
|
| gptkbp:OMIM |
138960
|
| gptkbp:pathway |
gptkb:MAPK_pathway
gptkb:JAK/STAT_pathway gptkb:PI3K_pathway |
| gptkbp:PDB |
2GMF
|
| gptkbp:producedBy |
gptkb:T_cells
macrophages endothelial cells fibroblasts |
| gptkbp:recipient |
GM-CSF receptor
heterodimeric |
| gptkbp:regulates |
induced by IL-1 and TNF-alpha
suppressed by glucocorticoids |
| gptkbp:role |
involved in autoimmune diseases
implicated in rheumatoid arthritis implicated in multiple sclerosis implicated in pulmonary alveolar proteinosis |
| gptkbp:secretes |
activated immune cells
|
| gptkbp:species |
gptkb:human
gptkb:mouse right |
| gptkbp:structure |
gptkb:protein
|
| gptkbp:studiedBy |
immunology research
hematopoiesis studies |
| gptkbp:target |
gptkb:eosinophils
dendritic cells macrophages neutrophils myeloid progenitor cells |
| gptkbp:UniProtID |
P04141
|
| gptkbp:usedAsDrug |
molgramostim
sargramostim |
| gptkbp:bfsParent |
gptkb:AP1
gptkb:eosinophils |
| gptkbp:bfsLayer |
7
|