Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:activatedBy |
gptkb:caspase-1
|
| gptkbp:alsoKnownAs |
Interleukin-18
|
| gptkbp:category |
cytokine
immune system protein |
| gptkbp:discoveredBy |
Tetsuji Nishida
|
| gptkbp:discoveredIn |
1995
|
| gptkbp:encodedBy |
gptkb:IL18_gene
|
| gptkbp:function |
involved in inflammatory response
enhances NK cell activity induces IFN-gamma production promotes Th1 cell differentiation |
| https://www.w3.org/2000/01/rdf-schema#label |
IL-18
|
| gptkbp:inhibitedBy |
IL-18 binding protein
|
| gptkbp:locatedOnChromosome |
11q22.2–q22.3
|
| gptkbp:molecularWeight |
18 kDa
|
| gptkbp:PDB |
3WO2
|
| gptkbp:predecessor |
pro-IL-18
|
| gptkbp:producedBy |
dendritic cells
macrophages epithelial cells |
| gptkbp:recipient |
IL-18R
|
| gptkbp:relatedTo |
gptkb:cancer
gptkb:Crohn's_disease asthma sepsis autoimmune diseases psoriasis rheumatoid arthritis |
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
pro-inflammatory cytokine
|
| gptkbp:UniProtID |
gptkb:Q14116
|
| gptkbp:bfsParent |
gptkb:IFN-γ
|
| gptkbp:bfsLayer |
7
|