|
gptkbp:instanceOf
|
gptkb:cytokine
|
|
gptkbp:activatedBy
|
gptkb:caspase-1
|
|
gptkbp:alsoKnownAs
|
Interleukin-18
|
|
gptkbp:category
|
gptkb:cytokine
immune system protein
|
|
gptkbp:discoveredBy
|
Tetsuji Nishida
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodedBy
|
gptkb:IL18_gene
|
|
gptkbp:function
|
involved in inflammatory response
enhances NK cell activity
induces IFN-gamma production
promotes Th1 cell differentiation
|
|
gptkbp:inhibitedBy
|
IL-18 binding protein
|
|
gptkbp:locatedOnChromosome
|
11q22.2–q22.3
|
|
gptkbp:molecularWeight
|
18 kDa
|
|
gptkbp:PDB
|
3WO2
|
|
gptkbp:predecessor
|
pro-IL-18
|
|
gptkbp:producedBy
|
dendritic cells
macrophages
epithelial cells
|
|
gptkbp:recipient
|
IL-18R
|
|
gptkbp:relatedTo
|
gptkb:cancer
gptkb:Crohn's_disease
asthma
sepsis
autoimmune diseases
psoriasis
rheumatoid arthritis
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
pro-inflammatory cytokine
|
|
gptkbp:UniProtID
|
gptkb:Q14116
|
|
gptkbp:bfsParent
|
gptkb:IFN-γ
gptkb:interleukin-18
gptkb:IL-1_family
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL-18
|