Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:discoveredIn |
1989
|
| gptkbp:fullName |
gptkb:Interleukin-12
|
| gptkbp:function |
enhances cytotoxic activity of NK cells
stimulates differentiation of naive T cells into Th1 cells induces production of IFN-gamma |
| gptkbp:gene |
gptkb:IL12A
gptkb:IL12B |
| https://www.w3.org/2000/01/rdf-schema#label |
IL-12
|
| gptkbp:involvedIn |
inflammation
immune response |
| gptkbp:involves |
multiple sclerosis
autoimmune diseases psoriasis rheumatoid arthritis inflammatory bowel disease |
| gptkbp:locatedOnChromosome |
gptkb:3p12-3q13.2_(IL12A)
gptkb:5q31.1-33.1_(IL12B) |
| gptkbp:producedBy |
dendritic cells
macrophages |
| gptkbp:promotion |
IFN-gamma production
TNF-alpha production NK cell activity |
| gptkbp:recipient |
gptkb:IL-12_receptor
|
| gptkbp:regulates |
innate immunity
T cell responses |
| gptkbp:structure |
heterodimer
|
| gptkbp:subunit |
p35
p40 |
| gptkbp:target |
gptkb:ustekinumab
gptkb:briakinumab |
| gptkbp:bfsParent |
gptkb:IFN-γ
gptkb:Il-12 |
| gptkbp:bfsLayer |
7
|