|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:KIT
gptkb:c-Kit
|
|
gptkbp:discoveredBy
|
S. Yarden et al.
|
|
gptkbp:encodedBy
|
gptkb:KIT_gene
|
|
gptkbp:expressedIn
|
gptkb:melanocytes
gptkb:mast_cells
gptkb:germ_cells
hematopoietic stem cells
|
|
gptkbp:firstDescribed
|
1987
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD117 (c-Kit)
|
|
gptkbp:ligand
|
gptkb:stem_cell_factor
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
|
|
gptkbp:molecularWeight
|
145 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
infertility
pigmentation disorders
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:role
|
apoptosis
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:significance
|
gptkb:mast_cell_disease
gptkb:acute_myeloid_leukemia
gastrointestinal stromal tumors
|
|
gptkbp:structure
|
transmembrane glycoprotein
|
|
gptkbp:target
|
gptkb:dasatinib
gptkb:imatinib
gptkb:sunitinib
|
|
gptkbp:UniProtID
|
P10721
|
|
gptkbp:bfsParent
|
gptkb:MGTA-456
gptkb:mast_cells
|
|
gptkbp:bfsLayer
|
7
|