|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:cellSurfaceMarker
|
yes
|
|
gptkbp:chromosomeArm
|
3q13.2
|
|
gptkbp:discoveredIn
|
2003
|
|
gptkbp:domain
|
Ig superfamily domain
|
|
gptkbp:downstreamSignaling
|
gptkb:PI3K
gptkb:SHP-2
gptkb:AKT
gptkb:ERK
gptkb:NF-κB
gptkb:SHP-1
|
|
gptkbp:encodedBy
|
gptkb:BTLA_gene
|
|
gptkbp:Entrez_Gene_ID
|
151888
ENSG00000186462
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:B_cells
gptkb:T_cells
dendritic cells
|
|
gptkbp:fullName
|
B and T lymphocyte attenuator
|
|
gptkbp:function
|
immunotherapy
inhibitory receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:17143
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BTLA
|
|
gptkbp:inhibitedBy
|
T cell activation
B cell activation
|
|
gptkbp:interactsWith
|
gptkb:TNFRSF14
|
|
gptkbp:ligand
|
HVEM
|
|
gptkbp:locatedOnChromosome
|
3
|
|
gptkbp:modulatedBy
|
apoptosis
cell proliferation
cytokine production
lymphocyte activation
|
|
gptkbp:molecularWeight
|
~33 kDa
|
|
gptkbp:motif
|
gptkb:ITIM
ITSM
|
|
gptkbp:OMIM
|
606671
|
|
gptkbp:orthologInMouse
|
Btla
|
|
gptkbp:potentialTherapeuticTarget
|
immunotherapy
|
|
gptkbp:regulates
|
inflammation
immune response
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
Q7Z6A9
|
|
gptkbp:bfsParent
|
gptkb:CD270
gptkb:CD272
|
|
gptkbp:bfsLayer
|
8
|