|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:BCL2_gene
|
|
gptkbp:expressedIn
|
gptkb:B_cells
various tissues
|
|
gptkbp:family
|
gptkb:Bcl-2_family
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
B-cell lymphoma 2 protein
|
|
gptkbp:function
|
regulation of apoptosis
inhibition of cell death
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bcl-2 protein
|
|
gptkbp:inhibitedBy
|
caspase activation
apoptotic cell death
|
|
gptkbp:interactsWith
|
Bak protein
Bcl-xL protein
Bad protein
Bax protein
|
|
gptkbp:involvedIn
|
cellular homeostasis
oncogenesis
intrinsic apoptotic pathway
|
|
gptkbp:involves
|
drug resistance
|
|
gptkbp:locatedOnChromosome
|
18q21.33
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
nuclear envelope
mitochondrial outer membrane
|
|
gptkbp:molecularWeight
|
26 kDa
|
|
gptkbp:mutationAssociatedWith
|
chronic lymphocytic leukemia
other cancers
follicular lymphoma
|
|
gptkbp:OMIM
|
151430
|
|
gptkbp:PDB
|
gptkb:1G5M
|
|
gptkbp:phosphorylates
|
Ser70
|
|
gptkbp:prevention
|
cytochrome c release
|
|
gptkbp:promotion
|
cell survival
|
|
gptkbp:regulates
|
post-translational modifications
mitochondrial membrane permeability
transcriptional
|
|
gptkbp:structure
|
transmembrane domain
contains BH domains
|
|
gptkbp:target
|
gptkb:oblimersen
gptkb:venetoclax
anticancer drugs
navitoclax
|
|
gptkbp:UniProtID
|
P10415
|
|
gptkbp:usedAs
|
biomarker
|
|
gptkbp:bfsParent
|
gptkb:Bcl-2_inhibitor_KCA-872
gptkb:FKBP38
gptkb:BCL2
|
|
gptkbp:bfsLayer
|
7
|