|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
BCL-X
BCL2-like 1
BCL2L
|
|
gptkbp:alternativeSplicing
|
produces Bcl-xL
produces Bcl-xS
|
|
gptkbp:associatedWith
|
gptkb:cancer
chemoresistance
|
|
gptkbp:discoveredBy
|
Boise et al., 1993
|
|
gptkbp:encodes
|
Bcl-x protein
|
|
gptkbp:Entrez_Gene_ID
|
598
ENSG00000171552
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
regulation of apoptosis
anti-apoptotic activity
pro-apoptotic activity (Bcl-xS isoform)
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1001
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BCL2L1
|
|
gptkbp:inhibitedBy
|
apoptosis (Bcl-xL isoform)
|
|
gptkbp:interactsWith
|
gptkb:BAD
gptkb:BID
gptkb:BAX
gptkb:BAK1
gptkb:BCL2
|
|
gptkbp:length
|
7 exons
|
|
gptkbp:locatedOnChromosome
|
gptkb:20q11.21
|
|
gptkbp:memberOf
|
BCL-2 protein family
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
|
|
gptkbp:OMIM
|
600039
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Bcl2l1
|
|
gptkbp:product
|
integral membrane protein
|
|
gptkbp:promotion
|
apoptosis (Bcl-xS isoform)
|
|
gptkbp:regulates
|
gptkb:NF-kB
gptkb:p53
gptkb:STAT3
cytochrome c release
mitochondrial outer membrane permeabilization
|
|
gptkbp:significance
|
target for cancer therapy
marker for prognosis in cancer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondrial outer membrane
|
|
gptkbp:UniProtID
|
gptkb:Q07817
|
|
gptkbp:bfsParent
|
gptkb:Bcl-xL
gptkb:BAK1
gptkb:BCL2
|
|
gptkbp:bfsLayer
|
7
|