|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
phosphoserine-containing proteins
phosphothreonine-containing proteins
|
|
gptkbp:discoveredBy
|
gptkb:Tony_Hunter
|
|
gptkbp:discoveredIn
|
1967
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
signal transduction
regulation of cell cycle
apoptosis regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
14-3-3 protein
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
neurodegenerative diseases
cancer progression
neurotransmitter release
cellular stress response
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
28-33 kDa
|
|
gptkbp:proteinFamily
|
YWH
|
|
gptkbp:regulates
|
gptkb:tau_protein
gptkb:CDC25_phosphatases
gptkb:glycogen_synthase_kinase_3
gptkb:protein_kinase_C
gptkb:p53_protein
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:synaptic_plasticity
apoptosis
transcription
ion channels
cellular metabolism
protein trafficking
RAF kinases
cell cycle checkpoints
|
|
gptkbp:significance
|
implicated in cancer
biomarker for Creutzfeldt-Jakob disease
implicated in Alzheimer's disease
implicated in Parkinson's disease
implicated in schizophrenia
|
|
gptkbp:structure
|
alpha-helical
dimeric
|
|
gptkbp:subunit
|
gptkb:YWHAB
gptkb:YWHAE
gptkb:YWHAG
gptkb:YWHAS
gptkb:YWHAZ
gptkb:SFN
YWHAT
|
|
gptkbp:bfsParent
|
gptkb:B-Raf_protein
|
|
gptkbp:bfsLayer
|
6
|