Anaplastic lymphoma kinase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene gptkb:enzyme
gptkbp:alternativeName	gptkb:ALK_tyrosine_kinase_receptor gptkb:NBLST3 gptkb:CD246_antigen
gptkbp:associatedWith	gptkb:anaplastic_large_cell_lymphoma gptkb:neuroblastoma gptkb:non-small_cell_lung_cancer
gptkbp:biologicalProcess	cell differentiation cell proliferation signal transduction ATP binding protein tyrosine kinase activity
gptkbp:discoveredBy	gptkb:Steven_A._Morris
gptkbp:discoveredIn	1994
gptkbp:domain	extracellular domain transmembrane domain protein kinase domain glycine-rich domain
gptkbp:encodedBy	gptkb:ALK_gene
gptkbp:Entrez_Gene_ID	238
gptkbp:expressedIn	gptkb:nervous_system brain
gptkbp:function	gptkb:receptor_tyrosine_kinase cell growth regulation neuronal development
gptkbp:HGNC_ID	427
https://www.w3.org/2000/01/rdf-schema#label	Anaplastic lymphoma kinase
gptkbp:locatedOnChromosome	chromosome 2 2p23
gptkbp:mutationAssociatedWith	gptkb:gene point mutation
gptkbp:OMIM	105590
gptkbp:orthologInMouse	gptkb:Alk
gptkbp:orthologInZebrafish	alk
gptkbp:PDB	gptkb:3LCS
gptkbp:phosphorylates	gptkb:tyrosine
gptkbp:proteinFamily	gptkb:protein_kinase_superfamily gptkb:insulin_receptor_subfamily
gptkbp:subcellularLocation	gptkb:cell_membrane gptkb:nucleus gptkb:cytoplasm
gptkbp:symbol	gptkb:ALK
gptkbp:targetOfDrug	gptkb:alectinib gptkb:brigatinib gptkb:ceritinib gptkb:crizotinib gptkb:lorlatinib
gptkbp:UniProtID	gptkb:Q9UM73
gptkbp:bfsParent	gptkb:CD246
gptkbp:bfsLayer	7