Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:anaplastic_lymphoma_kinase
gptkb:ALK |
| gptkbp:associatedWith |
gptkb:anaplastic_large_cell_lymphoma
gptkb:non-small_cell_lung_cancer |
| gptkbp:discoveredBy |
1994
|
| gptkbp:encodedBy |
gptkb:ALK_gene
|
| gptkbp:expressedIn |
gptkb:nervous_system
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
gptkb:receptor_tyrosine_kinase
|
| gptkbp:HGNC_ID |
427
|
| https://www.w3.org/2000/01/rdf-schema#label |
CD246 antigen
|
| gptkbp:locatedOnChromosome |
chromosome 2p23
|
| gptkbp:molecularWeight |
~220 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
|
| gptkbp:OMIM |
105590
|
| gptkbp:PDB |
gptkb:3LCS
|
| gptkbp:phosphorylates |
tyrosine residues
|
| gptkbp:role |
cell differentiation
cell growth oncogenesis |
| gptkbp:structure |
transmembrane protein
|
| gptkbp:target |
gptkb:alectinib
gptkb:ceritinib gptkb:crizotinib gptkb:lorlatinib |
| gptkbp:UniProtID |
gptkb:Q9UM73
|
| gptkbp:bfsParent |
gptkb:Anaplastic_lymphoma_kinase
|
| gptkbp:bfsLayer |
8
|