Statements (78)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Ataxia-telangiectasia
|
| gptkbp:code |
gptkb:ATM_protein
|
| gptkbp:discovered_by |
gptkb:Dr._Andrew_S._Wilkins
|
| gptkbp:function |
DNA damage response
|
| gptkbp:genetic_studies |
increased cancer risk
Ataxia-telangiectasia patients |
| gptkbp:has_role |
neuronal development
|
| gptkbp:has_variants |
ATM mutations
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATM gene
|
| gptkbp:interacts_with |
MRE11 protein
|
| gptkbp:involved_in |
cell cycle regulation
|
| gptkbp:is_associated_with |
gptkb:Oncology
gptkb:Kaposi's_sarcoma gptkb:pancreatic_cancer neurodegeneration bladder cancer gastrointestinal cancer head and neck cancer |
| gptkbp:is_essential_for |
cellular response to ionizing radiation
genomic integrity |
| gptkbp:is_expressed_in |
muscle tissue
various tissues adipose tissue heart tissue brain tissue lymphocytes liver tissue kidney tissue placenta tissue testis tissue |
| gptkbp:is_involved_in |
apoptosis regulation
cellular homeostasis cellular metabolism cellular stress response cellular proliferation cellular response to stress chromosomal stability tumor suppression cellular differentiation DNA double-strand break repair cellular signaling pathways cellular signaling cellular repair mechanisms cellular differentiation pathways cellular homeostatic mechanisms cellular signaling networks cellular growth regulation cellular repair processes cellular apoptosis cellular apoptosis regulation |
| gptkbp:is_linked_to |
gptkb:Oncology
gptkb:neuroblastoma gptkb:neurodegenerative_diseases ovarian cancer endometrial cancer immunodeficiency esophageal cancer germline mutations radiation sensitivity |
| gptkbp:is_part_of |
immune response
homologous recombination DNA damage checkpoint cellular signaling pathways DNA repair pathways cellular repair mechanisms cellular repair pathways cellular repair systems DNA damage response network DNA repair complex |
| gptkbp:is_recognized_as |
1990s
|
| gptkbp:is_regulated_by |
gptkb:ATM_protein
|
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
gptkb:gene_therapy
|
| gptkbp:located_in |
human chromosome 11q22.3
|
| gptkbp:related_to |
p53 pathway
|
| gptkbp:bfsParent |
gptkb:ATR_family
|
| gptkbp:bfsLayer |
6
|