|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:aggregationLeadsTo
|
neurodegeneration
|
|
gptkbp:alias
|
gptkb:SNCA
gptkb:NACP
gptkb:PARK1
|
|
gptkbp:aminoAcidLength
|
140
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
Lewy body dementia
|
|
gptkbp:component
|
Lewy bodies
|
|
gptkbp:discoveredBy
|
gptkb:Maroteaux_et_al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:SNCA_gene
|
|
gptkbp:expressedIn
|
brain
red blood cells
|
|
gptkbp:form
|
fibrils
oligomers
protofibrils
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
modulation of neurotransmitter release
regulation of synaptic vesicle trafficking
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
alpha-synuclein
|
|
gptkbp:interactsWith
|
gptkb:tau_protein
gptkb:synphilin-1
gptkb:14-3-3_protein
lipids
dopamine
|
|
gptkbp:involves
|
gptkb:REM_sleep_behavior_disorder
gptkb:multiple_system_atrophy
autonomic dysfunction
neuroinflammation
|
|
gptkbp:locatedIn
|
presynaptic terminals
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q22.1
|
|
gptkbp:molecularWeight
|
14 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_Parkinson's_disease
|
|
gptkbp:pathology
|
gptkb:synucleinopathy
|
|
gptkbp:phosphorylates
|
Serine 129
|
|
gptkbp:postTranslationalModification
|
phosphorylation
truncation
ubiquitination
nitration
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:target
|
gptkb:RNA_interference
antisense oligonucleotides
small molecule inhibitors
immunotherapy research
|
|
gptkbp:UniProtID
|
gptkb:P37840
|
|
gptkbp:bfsParent
|
gptkb:Parkin
|
|
gptkbp:bfsLayer
|
6
|