|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
14-3-3E
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
|
|
gptkbp:associatedWith
|
gptkb:Miller-Dieker_lissencephaly_syndrome
epilepsy
schizophrenia
|
|
gptkbp:discoveredBy
|
Aitken et al.
|
|
gptkbp:encodes
|
14-3-3 protein epsilon
|
|
gptkbp:Entrez_Gene_ID
|
7531
ENSG00000108953
|
|
gptkbp:expressedIn
|
brain
heart
liver
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:function
|
signal transduction
apoptosis regulation
cell cycle control
neuronal migration
|
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gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:YWHAB
gptkb:YWHAG
gptkb:YWHAS
gptkb:YWHAZ
gptkb:SFN
YWHAC
YWHAQ
|
|
gptkbp:HGNC_ID
|
HGNC:12852
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
YWHAE
|
|
gptkbp:interactsWith
|
gptkb:AKT1
gptkb:MAPK1
gptkb:BAD
gptkb:BAX
gptkb:RAF1
CDC25B
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability
neurodevelopmental disorders
|
|
gptkbp:OMIM
|
605066
|
|
gptkbp:orthologInMouse
|
Ywhae
|
|
gptkbp:participatedIn
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
apoptosis pathway
|
|
gptkbp:proteinFamily
|
14-3-3 protein family
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:UniProtID
|
P62258
|
|
gptkbp:bfsParent
|
gptkb:14-3-3_proteins
gptkb:17p13.2
gptkb:14-3-3_protein
gptkb:17p13
|
|
gptkbp:bfsLayer
|
7
|