CD4+ T cells

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf T cell subtype
gptkbp:activatedBy antigen-presenting cells
gptkbp:alsoKnownAs T helper cells
gptkbp:decreasedIn immunodeficiency
gptkbp:depletedIn gptkb:AIDS
gptkbp:developedBy thymocytes
gptkbp:distinctiveFeature gptkb:Tfh_cells
gptkb:Th17_cells
gptkb:Th1_cells
gptkb:Th2_cells
gptkb:Treg_cells
gptkbp:expressedIn gptkb:CD4_glycoprotein
gptkbp:firstDescribed gptkb:Ellis_L._Reinherz
1979
gptkbp:foundIn blood
lymphoid tissues
gptkbp:function activate B cells
activate cytotoxic T cells
activate macrophages
coordinate immune response
https://www.w3.org/2000/01/rdf-schema#label CD4+ T cells
gptkbp:improves autoimmune diseases
certain infections
gptkbp:involves transplant rejection
gptkbp:marking gptkb:TCR
gptkb:CD3
gptkb:CD4
gptkbp:measures flow cytometry
gptkbp:normalCountInBlood 500-1500 cells/μL
gptkbp:produces cytokines
gptkbp:proliferatesInResponseTo antigen stimulation
gptkbp:recipient gptkb:T_cell_receptor_(TCR)
gptkbp:recognizedBy gptkb:antigen_presented_by_MHC_class_II
gptkbp:requires cell-mediated immunity
vaccine response
antibody production
gptkbp:role autoimmune diseases
adaptive immunity
immunological memory
allergic responses
gptkbp:secretes gptkb:interferon-gamma
gptkb:interleukin-2
gptkb:interleukin-4
gptkb:tumor_necrosis_factor-alpha
gptkbp:studiedIn immunology
gptkbp:subspecies white blood cell
lymphocyte
gptkbp:target gptkb:HIV
gptkbp:bfsParent gptkb:HIV
gptkbp:bfsLayer 5