|
gptkbp:instanceOf
|
gptkb:T_cell_subtype
|
|
gptkbp:activatedBy
|
antigen-presenting cells
|
|
gptkbp:alsoKnownAs
|
T helper cells
|
|
gptkbp:decreasedIn
|
gptkb:immunodeficiency
|
|
gptkbp:depletedIn
|
gptkb:AIDS
|
|
gptkbp:developedBy
|
thymocytes
|
|
gptkbp:distinctiveFeature
|
gptkb:Tfh_cells
gptkb:Th17_cells
gptkb:Th1_cells
gptkb:Th2_cells
gptkb:Treg_cells
|
|
gptkbp:expressedIn
|
gptkb:CD4_glycoprotein
|
|
gptkbp:firstDescribed
|
gptkb:Ellis_L._Reinherz
1979
|
|
gptkbp:foundIn
|
blood
lymphoid tissues
|
|
gptkbp:function
|
activate B cells
activate cytotoxic T cells
activate macrophages
coordinate immune response
|
|
gptkbp:improves
|
autoimmune diseases
certain infections
|
|
gptkbp:involves
|
transplant rejection
|
|
gptkbp:marking
|
gptkb:TCR
gptkb:CD3
gptkb:CD4
|
|
gptkbp:measures
|
flow cytometry
|
|
gptkbp:normalCountInBlood
|
500-1500 cells/μL
|
|
gptkbp:produces
|
cytokines
|
|
gptkbp:proliferatesInResponseTo
|
antigen stimulation
|
|
gptkbp:recipient
|
gptkb:T_cell_receptor_(TCR)
|
|
gptkbp:recognizedBy
|
gptkb:antigen_presented_by_MHC_class_II
|
|
gptkbp:requires
|
cell-mediated immunity
vaccine response
antibody production
|
|
gptkbp:role
|
autoimmune diseases
adaptive immunity
immunological memory
allergic responses
|
|
gptkbp:secretes
|
gptkb:interferon-gamma
gptkb:interleukin-2
gptkb:interleukin-4
gptkb:tumor_necrosis_factor-alpha
|
|
gptkbp:studiedIn
|
immunology
|
|
gptkbp:subspecies
|
gptkb:white_blood_cell
gptkb:lymphocyte
|
|
gptkbp:target
|
gptkb:HIV
|
|
gptkbp:bfsParent
|
gptkb:HIV
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD4+ T cells
|