transforming growth factor beta

URI: https://gptkb.org/entity/transforming_growth_factor_beta
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:TGF-β
gptkbp:activatedBy gptkb:SMAD_proteins
gptkbp:binds TGF-beta receptors
gptkbp:category growth factor
signaling molecule
cytokine
gptkbp:discoveredIn 1980s
gptkbp:family gptkb:TGF-beta_superfamily
gptkbp:function regulation of apoptosis
regulation of cell differentiation
regulation of cell growth
regulation of immune system
gptkbp:gene gptkb:TGFB1
gptkb:TGFB2
gptkb:TGFB3
gptkbp:hasIsoform TGF-beta 1
TGF-beta 2
TGF-beta 3
https://www.w3.org/2000/01/rdf-schema#label transforming growth factor beta
gptkbp:inhibitedBy gptkb:alpha2-macroglobulin
gptkb:decorin
epithelial cell proliferation
gptkbp:location extracellular space
gptkbp:modulatedBy cell proliferation
inflammation
immune cell function
extracellular matrix production
gptkbp:pathway SMAD signaling pathway
gptkbp:producedBy many cell types
gptkbp:promotion collagen synthesis
fibroblast proliferation
gptkbp:recipient gptkb:TGF-beta_receptor_type_I
gptkb:TGF-beta_receptor_type_II
gptkb:TGF-beta_receptor_type_III
gptkbp:regulates apoptosis
gene expression
angiogenesis
cell cycle
immune tolerance
gptkbp:role gptkb:cancer
gptkb:cardiovascular_disease
wound healing
autoimmune diseases
embryogenesis
fibrosis
gptkbp:structure dimeric protein
gptkbp:bfsParent gptkb:TGF-beta_research_community
gptkbp:bfsLayer 7