transformation-related protein 53

URI: https://gptkb.org/entity/transformation-related_protein_53
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:p53
gptkbp:discoveredBy gptkb:Arnold_Levine
gptkb:David_Lane
gptkbp:discoveredIn 1979
gptkbp:encodedBy gptkb:TP53_gene
gptkbp:Entrez_Gene_ID 7157
gptkbp:expressedIn gptkb:nucleus
gptkb:cytoplasm
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function tumor suppressor
transcription factor
gptkbp:GO gptkb:GO:0008285
GO:0003677
GO:0006355
GO:0006977
https://www.w3.org/2000/01/rdf-schema#label transformation-related protein 53
gptkbp:interactsWith gptkb:CBP/p300
gptkb:BAX
gptkb:GADD45
gptkb:p21
gptkb:MDM2
gptkb:BRCA1
gptkb:E2F1
gptkb:14-3-3σ
ATM
gptkbp:locatedOnChromosome 17p13.1
gptkbp:molecularWeight ~53 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
gptkbp:OMIM 191170
gptkbp:PDB 1TUP
gptkbp:postTranslationalModification phosphorylation
methylation
sumoylation
ubiquitination
acetylation
gptkbp:regulates apoptosis
DNA repair
metabolism
cellular senescence
angiogenesis
cell cycle
senescence
cellular response to stress
gptkbp:significance gptkb:Li-Fraumeni_syndrome
somatic mutations in many cancers
gptkbp:structure tetramer
gptkbp:UniProtID P04637
gptkbp:bfsParent gptkb:NP_031401
gptkbp:bfsLayer 7