Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alias |
DNA topoisomerase II binding protein 1
TOPBP TOPBP1_HUMAN |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
|
| gptkbp:discoveredIn |
1999
|
| gptkbp:domain |
gptkb:BRCT_domain
|
| gptkbp:encodes |
DNA topoisomerase 2-binding protein 1
|
| gptkbp:Entrez_Gene_ID |
11200
ENSG00000109771 |
| gptkbp:function |
DNA replication
DNA damage response cell cycle checkpoint control |
| https://www.w3.org/2000/01/rdf-schema#label |
TOPBP1
|
| gptkbp:interactsWith |
gptkb:ATR
gptkb:MDC1 gptkb:BRCA1 gptkb:E2F1 RAD9A |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_3
3q22.1 |
| gptkbp:molecularWeight |
180 kDa
|
| gptkbp:OMIM |
604522
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:phosphorylates |
yes
|
| gptkbp:subcellularLocation |
gptkb:nucleus
|
| gptkbp:UniProtID |
Q92547
|
| gptkbp:bfsParent |
gptkb:topoisomerase_II_alpha
gptkb:BRIP1 |
| gptkbp:bfsLayer |
7
|